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How CBG Compares to THC and CBD

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Think of CBG (cannabigerol) as the mother of all cannabinoids. It’s much less abundant in cannabis than popular THC and CBD but acts like a “stem cell”, from which CBD and THC are formed.

Fast facts about CBG:

Intoxicating or non-intoxicating?

CBG (like CBD) is non-intoxicating, which means it doesn’t get you high.

Abundance in the cannabis plant?

<1% in most cannabis plants, so it’s considered a minor cannabinoid

What cannabinoid receptor does it act on?

CBG acts partially on both the CB1 and CB2 receptors, but it can also affect the body by increasing our endocannabinoid, anandamide which binds directly to both receptors.

Latest research on health benefits? 

The medical benefits of CBG are still being researched, however there is an impressive list of potential benefits from pre-clinical trials, which is getting scientists and cannabinoid enthusiasts alike excited.

  • It’s well documented that THC can help people suffering from depression and anxiety. CBG has been found to have similar effects but without the high that THC is famous for. A 2016 report suggests that non-intoxicating cannabinoids like CBG may be alternatives for treating anxiety and depression.
  • In mice, CBG was found to be effective in decreasing the inflammation similar to that experienced by humans with inflammatory bowel disease.
  • In a 2015 study, CBG was shown to protect neurons in mice with Huntington’s disease, showing promise for protecting nerve cell degeneration in the brain.
  • Now this is a biggie, CBG has some exciting prospects as a cancer fighter, specifically, it had the ability to block receptors to inhibit the growth of colorectal cancer cells in mice, thus slowing colon cancer growth.
  • CBG tested best at inhibiting muscle contractions, in a study that looked at the effects of five different cannabinoids on bladder contractions, so it may be a tool for preventing bladder disorders.
  • In a 1990 study, treatment with THC and CBG increased aqueous flow up to three fold in animal models of glaucoma. This shows promise for helping reduce pressure inside the oculus in cases of glaucoma for human patients

How does it work?

  • CBG has been shown to inhibit the uptake of GABA, a chemical in the brain that regulates the activity of neurons which links to it’s neuroprotective qualities shown in mice with Huntington’s
  • It’s been shown to block serotonin receptors, linked to its potential to play a key role in treating anxiety and depression
  • It can also act on the central nervous system without causing a high

Why CBG & CBD together?

The combination of these two, potent non-intoxicating cannabinoids creates a holistic effect acting to both bind to our cannabinoid receptors and stimulate production of our own edocannabinoids to balance mind and body.